Drugs That May Cause Psychatric Symptoms

Two african american pharmacist working in drugstore at hospital pharmacy. African healthcare.

Many drugs can cause psychiatric symptoms, but a causal connection is often difficult to establish. Psychiatric symptoms that emerge during drug treatment could also be due to the underlying illness, previously unrecognized psychopathology, or psychosocial factors. The withdrawal of some drugs can cause symptoms such as anxiety, psychosis, delirium, agitation or depression.

This website list some drug classes and some specific drugs reported to cause psychiatric symptoms. Such symptoms are reported uncommonly with most of the drugs listed. Alcohol, hallucinogens and other drugs not generally used for medical treatment in the US are not included. Withdrawal reactions in patients dependent on opioids and physiological reactions to drugs such as insulin have also been omitted. The table is limited to psychiatric symptoms reported with single drugs, but drug interactions can also cause such symptoms (The Medical Letter Adverse Drug Interactions Program). 


Intended Audience
N/A

Provided by
Medical Letter


Last Updated:
July 18, 2023