This resource provided by IPRO QIN-QIO is for health care professionals and discusses information describing what naloxone is, how it works, why it is offered to individuals with an opioid prescription, and signs of opioid overdose. It is available in both Spanish and English. Recognizing that patients may not be comfortable speaking about naloxone due to stigma associated with opioid use The Naloxone Conversation Starter for Pharmacists guides pharmacists through the potentially difficult conversation when offering naloxone to patients at risk for opioid overdose.